I Just did and although the game opened it immediately went to an "Error loading mods" page.
It says:
Mod embeddium only supports textrues_embeddium_options 0.0.0-NOT-COMPATIBLE
Currently, textrues_embeddium_options is 0.1.5+mc1.20.1
https://mclo.gs/7GUOmLd
--edit--
1) Turned off the Embeddium mod and its dependents--The game opened up and is running, but I think that's what was used to run my shaders. So now I have vanilla lighting and textures. The framerate has dropped some too and its taking longer to load the surrounding chunks. No errors, but no shaders.
2) On my other world it froze again when I approached a custom structure from the Hexerei mod. It's telling me that I need to allocate more memory to it, but I don't have any more memory that I can give without locking up my PC altogether. This is a different problem that, unless you have suggestions, I think I'll need to talk with the mod maker about specifically.